All Studies
Oral Device Effectiveness
Oral Device vs. CPAP
Heart Health Studies
Brain Health Studies
Metabolic Health Studies
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Snoring Studies
Sleep Apnea and Chronic Pain
How Poor Sleep Affects your Risk of Dementia
Journal of the American Medical Association
January 1, 2021
X Close
Key Finding:
Poor Sleep is a factor in Amloid Development in the Brain, which is a risk factor for dementia
Read the Full Study Here
Chronic Pain and Sleep Apnea
Science Signaling
July 30, 2024
X Close
Key Finding:
The findings indentify a target to potentially reduce chronic pain in patients with sleep apnea.
Read the Full Study Here
Peripheral macrophages contribute to nociceptor priming in mice with chronic intermittent hypoxia
Science Signaling
July 30, 2024
X Close
Key Finding:
The hypoxic aspect of sleep apnea causes increased sensitivity to pain
Read the Full Study Here
Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy
Cureus
December 1, 2023
X Close
Key Finding:
89% of Patient were treated effectively with an Oral Device
Read the Full Study Here
Assessing precision oral appliance efficacy using frequency and risk based indices
Sleep
May 1, 2023
X Close
Key Finding:
Precision Oral Appliance Therapy significantly improved Sleep Apnea Specific Hypoxic Burden
Read the Full Study Here
Mandibular Advancement vs. CPAP for Blood Pressure Reduction in Patients with Obstructive Sleep Apnea
Journal of the American College of Cardiology
May 1, 2024
X Close
Key Finding:
Oral Devices equal to CPAP for Reducing Blood Pressure
Read the Full Study Here
Health Outcomes of CPAP vs. Oral Appliance
American Journal of Respiratory and Critical Care Medicine
X Close
Key Finding:
Important health outcomes were similar after 1 month of optimal Mandibular Advancement Device and CPAP treatment
Read the Full Study Here
CPAP for prevention of Cardiovascular Events in Obstructive Sleep Apnea
The New England Journal of Medicine
September 8, 2016
X Close
Key Finding:
CPAP did not prevent cardiovascular events in patients with moderate to severe OSA.
Read the Full Study Here
CPAP Therapy Termination Rates by OSA Phenotype
Journal of Clinical Medicine
March 1, 2021
X Close
Key Finding:
Around 50% of CPAP users end up terminating treatment. We need non-CPAP Therapies for OSA.
Read the Full Study Here
Association between self-reported snoring and hypertension: a systematic review and meta-analysis
Sleep Medicine
December 1, 2021
X Close
Key Finding:
Snoring significantly increased the risk of hypertension in both men and women
Read the Full Study Here
Snoring Is Associated With Increased Risk of Stroke, A Cumulative Meta-Analysis
Frontiers in Neurology
April 1, 2021
X Close
Key Finding:
Snoring is associated with up to a 46% increased risk of stroke.
Read the Full Study Here
Snoring Is Associated With Increased Risk of Stroke
Frontiers in Neurology
April 1, 2021
X Close
Key Finding:
Snoring is associated with up to a 46% increased risk of stroke.
Read the Full Study Here
Association of Sleep-disordered Breathing and the Occurrence of Stroke
American Journal of Respiratory and Critical Care Medicine
December 1, 2005
X Close
Key Finding:
[There is] a strong association between moderate to severe sleep-disordered breathing and prevalent stroke, independent of confounding factors.
Read the Full Study Here
Obstructive sleep apnea as a risk factor for stroke and death
New England Journal of Medicine
November 10, 2005
X Close
Key Finding:
Researchers have know since 2005 that obstructive sleep apnea causes a statistically significant association with stroke or death
Read the Full Study Here
Vibration enhances interleukin-8 release in a cell model of snoring-induced airway inflammation
Sleep
October 1, 2005
X Close
Key Finding:
Snoring may increase your inflammatory response [such as in allergies]
Read the Full Study Here
Vibration injury damages arterial endothelial cells
Muscle Nerve
April 1, 2002
X Close
Key Finding:
Electron microscopy revealed that vibration for 9 days produced loss and thinning of endothelial cells, with activated platelets coating the exposed subendothelial tissue.
Read the Full Study Here
Habitual Snoring as a Risk Factor for Brain Infarction
Acta Neurol Scand
July 1, 1995
X Close
Key Finding:
Habitual snoring carries a significant risk factor for stoke
Read the Full Study Here
Heavy snoring as a cause of Carotid Atherosclerosis
Sleep
January 9, 2008
X Close
Key Finding:
Heavy snoring significantly increases the risk of carotid atherosclerosis [hardening of the arteries]
Read the Full Study Here
Long-term follow-up of a randomized controlled trial of oral appliance therapy in obstructive sleep apnea
Respiration
March 1, 2011
X Close
Key Finding:
Mandibular Advancement Device shows significant reduction in number of sleep disordered breathing events
Read the Full Study Here
JCSM MATRx Study
Journal of Clinical Sleep Medicine
January 3, 2023
X Close
Key Finding:
Oral Devices 96% Effective in Treatment of Mild and Moderate Sleep Apnea. 81% Effective in Treatment of Severe Sleep Apnea
Read the Full Study Here
Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy
Cureus
December 1, 2023
See Key GraphIkonik Icon
X Close
Key Finding:
89% of Patient were treated effectively with an Oral Device
Read the Full Study Here
Assessing precision oral appliance efficacy using frequency and risk based indices
Sleep
May 1, 2023
See Key GraphIkonik Icon
X Close
Key Finding:
Precision Oral Appliance Therapy significantly improved Sleep Apnea Specific Hypoxic Burden
Read the Full Study Here
JCSM MATRx Study
Journal of Clinical Sleep Medicine
January 3, 2023
See Key GraphIkonik Icon
X Close
Key Finding:
Oral Devices 96% Effective in Treatment of Mild and Moderate Sleep Apnea. 81% Effective in Treatment of Severe Sleep Apnea
Read the Full Study Here
Health Outcomes of CPAP vs. Oral Appliance
American Journal of Respiratory and Critical Care Medicine
See Key GraphIkonik Icon
X Close
Key Finding:
Important health outcomes were similar after 1 month of optimal Mandibular Advancement Device and CPAP treatment
Read the Full Study Here
CPAP for prevention of Cardiovascular Events in Obstructive Sleep Apnea
The New England Journal of Medicine
September 8, 2016
See Key GraphIkonik Icon
X Close
Key Finding:
CPAP did not prevent cardiovascular events in patients with moderate to severe OSA.
Read the Full Study Here
CPAP Therapy Termination Rates by OSA Phenotype
Journal of Clinical Medicine
March 1, 2021
See Key GraphIkonik Icon
X Close
Key Finding:
Around 50% of CPAP users end up terminating treatment. We need non-CPAP Therapies for OSA.
Read the Full Study Here
Long-term follow-up of a randomized controlled trial of oral appliance therapy in obstructive sleep apnea
Respiration
March 1, 2011
See Key GraphIkonik Icon
X Close
Key Finding:
Mandibular Advancement Device shows significant reduction in number of sleep disordered breathing events
Read the Full Study Here
Mandibular Advancement vs. CPAP for Blood Pressure Reduction in Patients with Obstructive Sleep Apnea
Journal of the American College of Cardiology
May 1, 2024
See Key GraphIkonik Icon
X Close
Key Finding:
Oral Devices equal to CPAP for Reducing Blood Pressure
Read the Full Study Here
How Poor Sleep Affects your Risk of Dementia
Journal of the American Medical Association
January 1, 2021
See Key GraphIkonik Icon
X Close
Key Finding:
Poor Sleep is a factor in Amloid Development in the Brain, which is a risk factor for dementia
Read the Full Study Here
Peripheral macrophages contribute to nociceptor priming in mice with chronic intermittent hypoxia
Science Signaling
July 30, 2024
See Key GraphIkonik Icon
X Close
Key Finding:
The hypoxic aspect of sleep apnea causes increased sensitivity to pain
Read the Full Study Here
Snoring Is Associated With Increased Risk of Stroke, A Cumulative Meta-Analysis
Frontiers in Neurology
April 1, 2021
See Key GraphIkonik Icon
X Close
Key Finding:
Snoring is associated with up to a 46% increased risk of stroke.
Read the Full Study Here
Association of Sleep-disordered Breathing and the Occurrence of Stroke
American Journal of Respiratory and Critical Care Medicine
December 1, 2005
See Key GraphIkonik Icon
X Close
Key Finding:
[There is] a strong association between moderate to severe sleep-disordered breathing and prevalent stroke, independent of confounding factors.
Read the Full Study Here
No items found.
No items found.
No items found.
Chronic Pain and Sleep Apnea
Science Signaling
July 30, 2024
X Close
Key Finding:
The findings indentify a target to potentially reduce chronic pain in patients with sleep apnea.
Read the Full Study Here

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